Abstract:
Petroleum-ether, chloroform, and methanol extracts from Tylosema fassoglenssis (Caesalpiniaceae) were investigated for their in-vitro antimicrobial properties. A total of six microbial organisms belonging to five bacteria and one yeast species were studied using a disk-diffusion assay and minimum inhibition concentration (MIC) techniques. The result showed that none of the microorganisms tested was sensitive towards the petroleum-ether extract. The methanol and chloroform extracts exhibited anticandidal and antibacterial effects. Both the methanol and chloroform extracts, inhibited four isolates out of the five bacterial strains studied. The methanol extract showed a stronger antimicrobial activity than the chloroform extract judging from the sizes of inhibition zones. The minimim inhibition zones (MIC) of the methanol and chloroform extracts ranged from 125 to 250 µl/ml and 125 to 300 µl/ml, respectively. This study suggests that T. fassoglenssis, which is currently used in traditional medicine, is a potential source of antimicrobial compounds.
